GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12196860 | 1 | rs10807510 | chr6:56006672 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -7.02 | 3.93E-12 | Psychosis (atypical) |
| BRCA | cis | rs2243480 | 1 | rs10807701 | chr7:65724686 | CCT6P1 | chr7:65216092-65228661:+ | -0.29 | -6.39 | 2.48E-10 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs10807701 | chr7:65724686 | CRCP | chr7:65579805-65619551:+ | 0.21 | 3.67 | 0.000255 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs10807701 | chr7:65724686 | LOC493754 | chr7:65993446-66057363:- | -0.23 | -3.98 | 7.39E-5 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs10807702 | chr7:65767843 | CCT6P1 | chr7:65216092-65228661:+ | 0.25 | 5.39 | 8.47E-8 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs10807702 | chr7:65767843 | CRCP | chr7:65579805-65619551:+ | -0.28 | -4.76 | 2.21E-6 | Diabetic kidney disease |
| BRCA | cis | rs10808739 | 1 | rs10808739 | chr8:65640260 | CYP7B1 | chr8:65508529-65711348:- | -0.12 | -3.86 | 0.000122 | HIV-1 susceptibility |
| BRCA | cis | rs4879670 | 1 | rs10813961 | chr9:33207050 | NFX1 | chr9:33290510-33371154:+ | -0.14 | -3.84 | 0.000129 | Diabetic kidney disease |
| BRCA | cis | rs881375 | 1 | rs10818480 | chr9:123643170 | LOC253039 | chr9:123605320-123616644:+ | -0.36 | -10.16 | 3.29E-23 | Rheumatoid arthritis |
| BRCA | cis | rs881375 | 1 | rs10818480 | chr9:123643170 | TRAF1 | chr9:123664672-123691479:- | 0.1 | 4.92 | 9.77E-7 | Rheumatoid arthritis |
| BRCA | cis | rs7849270 | 1 | rs10819466 | chr9:131881492 | SH3GLB2 | chr9:131770314-131790579:- | -0.13 | -4.86 | 1.37E-6 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819469 | chr9:131882067 | SH3GLB2 | chr9:131770314-131790579:- | -0.13 | -4.79 | 1.88E-6 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | C9orf119 | chr9:131038425-131051267:+ | -0.12 | -3.65 | 0.000279 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | CIZ1 | chr9:130928345-130966662:- | -0.13 | -3.52 | 0.000442 | Blood metabolite ratios |
| BRCA | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | COQ4 | chr9:131084791-131096349:+ | -0.1 | -4.16 | 3.51E-5 | Blood metabolite ratios |